Statistical methods in genetics

Statistical methods in genetics

In recent years, a very large variety of statistical methodologies, at various levels of complexity, have been put forward to analyse genotype data and detect genetic variations that may be responsible for increasing the susceptibility to disease. This review provides a concise account of a number of selected statistical methods for population-based association mapping, from single-marker tests...

Statistical methods in spatial genetics.

The joint analysis of spatial and genetic data is rapidly becoming the norm in population genetics. More and more studies explicitly describe and quantify the spatial organization of genetic variation and try to relate it to underlying ecological processes. As it has become increasingly difficult to keep abreast with the latest methodological developments, we review the statistical toolbox avai...

Bayesian Methods in Fisher’s Statistical Genetics World

Statistical genetics is a scientific discipline that covers any statistical analysis of genetic data. The interplay between statistics and genetics has a long history, dating back to the seminal work by Fisher almost a century ago to confirm the genetic theory of chromosomal inheritance (Piegorsch, 1990). Recent advancements in genotyping (i.e., collecting genetic data) technologies have produc...

Statistical Genetics

Statistical Genetics and Evolution

Introduction. When Darwin developed the theory of evolution by natural selection, practically nothing was known of hereditary differences beyond their existence. Since 1900, a body of knowledge on the mechanism of heredity and on mutation has been built up by experiment that challenges any field in the biological sciences in the extent and precision of its results. The implications for evolutio...